Crystallization & Process Engineering (crystproceng) Research group
Horizon Europe keywords:
· Artificial Intelligence and Robotics
· Manufacturing technologies
· Next generation computing and data technologies
· Pharmaceutical technologies
H-1117 Budapest, Bertalan lajos utca, BME FII building, office 17
Introduction of the Research Group
A young and dynamic research group focusing on the application of classical and cutting-edge process engineering methods in chemical, pharmaceutical, and food engineering. Our belief is that smart, flexible, well-operated and timely diagnosed manufacturing systems are key to maintaining our standards of living and improving those in need. This is also fundamental to stopping resource and energy waste and protecting the environment. To put these into practice, we apply mathematics (including numerical methods and advanced computing infrastructures) to solve practical and theoretical engineering problems related to chemical processes and product design.Our current focus covers a broad range, from the small-scale, fundamental understanding of unclarified aspects of complex phenomena, eg nucleation of solid particles from pure and impure liquids, to large-scale process operations and developments, combined data, and mechanistic model- based technology screenings as well as smart, model-based technology operations. We work on laboratory implementations and demonstrations of these concepts as well as to bring them closer to reality.
Watch our 3-minute introductory video:
Achievements
Established industrial collaborations with major local pharma companies,
Collaboration with local chemical companies beyond pharmaceuticals,
Significant national and international academic collaborators,
National and international research projects,
International academic and industrial network.
Publications
-Szilágyi, B., 2022. External fine particle removal for crystallization processes: Introduction and systematic comparison with the temperature cycling-based fines removal. Chem. Eng. Process. - Process Intensif. 179, 109074.
-Szilagyi, B., Eren, A., L. Quon, J., D. Papageorgiou, C., K. Nagy, Z., 2020a. Application of Model-Free and Model-Based Quality-by-Control (QbC) for the Efficient Design of Pharmaceutical Crystallization Processes. Cryst. Growth Des. 20, pp. 3979–3996.
-Szilagyi, B., Nagy, ZK, 2019. Model-based analysis and quality-by-design framework for high aspect ratio crystals in crystallizer-wet mill systems using GPU acceleration-enabled optimization. Computer. Chem. Eng. 126, 421–433.
-Szilagyi, B., Pal, K., Beheshti Tabar, I., Nagy, ZK, 2020c. A Novel Robust Digital Design of a Network of Industrial Continuous Cooling Crystallizers of Dextrose Monohydrate: From Laboratory Experiments to Industrial Application. Ind. Eng. Chem. Res. 59, 22231–22246.
Szilagyi, B., Wu, W.-L., Eren, A., Mackey, J., Kshirsagar, S., Szilagyi, E., Ostergaard, I., Qu, H., Sinha, K., Mlinar, L., Pohlman, D., Chen, J., Nere, N., Boukerche, M., Korde, A., Ellis, R., Lovette, M., Black, S., Jawor-Baczynska, A., Li, H., Yang, B.-S., Irdam, E., Patience, D., McKeown, R., Ketchum, M., Green, DA, Reddy, VR, Polster, C., Burcham, C. , Jarmer, D., Merritt, JM, Cote, A., Sirota, E., Codan, L., Schoell, J., Liu, YC, Girard, KP, Kulkarni, SA, Yang, Y., Quon, JL. . . . , Nagy, ZK, 2021. Cross-Pharma Collaboration for the Development of a Simulation Tool for the Model-Based Digital Design of Pharmaceutical Crystallization Processes (CrySiV). Cryst. Growth Des. 21, pp. 6448–6464.
Patents
Disclosed software: Crystallization Simulation and Visualization Tool (CrySiV), Purdue University, Zoltan K. Nagy and Botond SzilagyiJournals
Crystal growth and design
Chemical engineering research and design
Computers and chemical engineering
Infrastructure
Automated, computer-controlled laboratory reactor (0.5L)
Workstation
Projects
| OTKA FK 138475 (2022-2026), PI Marie Curie IF (2021-2023), Fellow |
Industry relations
Current:
Hungana
Yes
Gideon Richter
Mol
Synthon
Blaze Metrics
Past:
ADM
Takeda
AstraZeneca
Pfizer
Biogen
Amgen
GSK
Boehringer Ingelheim
Merck
Ely Lilly
AbbVie