- optical modeling of the human eye using different optical design programs, combining models based on beam transmission and diffraction to describe imaging as accurately as possible over the entire retina
- to model the path of light through the retinal nerve cell layers, taking into account as accurately as possible the possibilities of scattering, absorption and waveguiding in glial cells, throughout the retina
- to study the mechanism of light perception, in particular the relationship between the modeled optical image formed on the retina and the local distribution and type of photoreceptors
- to investigate theoretically and experimentally the mechanism and the basis of functioning of receptive fields
- modeling of interference and diffraction phenomena during the passage of light through the retina tissue, theoretical and experimental investigation of the correlation with the distribution of sensory cells.
- theoretical and experimental investigation of photoreceptor perception in low-light environments with a few photons of light input, investigating the influence of possible quantum mechanical effects on perception
- to demonstrate quantum mechanical effects on photoreceptor perception of light under single-photon illumination, both theoretically and experimentally
- information-theoretical and semiotic evaluation and modeling of the detection of light and further signal processing by the different receptive and neural components of the retina
- effects of interference and diffraction phenomena appearing during the passage of photons through the retina on categorization, perception and cognitive processes and judgments of the individual
- medical-diagnostic, evolutionary, communicative, psychological, epistemological, natural and philosophical aspects of the results
- optimized and customized numerical optical models of the human eye based on real measured patient data to precisely calculate imaging and transmission through the optical system of the eye
- developed custom optical models of mouse eyes to support the design of optical systems for in-vivo microscopy
- design and fabrication of adapter lenses for in vivo two-photon microscopy of mouse eyes and enhancement of visual stimulation of mice during in vivo experiments
- design of adapter lenses and adaptive optical relays for in vivo two-photon microscopy of human eyes
- in vivo and in vitro two-photon measurements on mouse retinas based on autofluorescence and genetically engineered calcium indicators to measure photosensitivity of retinal photosensor cells and to accurately determine the laser power at the limit of cell damage
- optical modeling and measurement of artificial intraocular lenses (IOLs) to optimize the design and manufacture of new artificial eye lens versions – especially multifocal lenses of different material types
- development and optimization of new laser technology for the fabrication of multifocal artificial lenses in polymers
- fabrication of fixed and portable sources for single photons and entangled photon pairs
- efficient quantum optical measurements eg Hong Ou Mandel effect
Publications
- Levente Szabó, Gábor Erdei, Pál Maák: Optical analysis of Müller glia cells as light transporters through the retina, Biomedical Optics Express 13(12), 6335-6356 (2022).
- Holló, Csaba T. ; Sarkadi, Tamás ; Galambos, Máté ; Bíró, Dániel ; Barócsi, Attila ; Koppa, Pál ; Erdei, Gábor
-Csilla Fülep, Illés Kovács, Kinga Kránitz, Gábor Erdei: Simulation of visual acuity by personalizable neuro-physiological model of the human eye. Scientific Reports (Nature) 9(1), 7805 (2019).
- Levente Szabó: Non-trivial quantum phenomena in perception and categorization processes. The interaction of signification. Jel-Kép 2019/1, 81–127 (2019).
-Akos Kusnyerik, Rozsa Balazs, Mate Veress, Arnold Szabo, Janos Nemeth, Pal Maak: Modeling of in vivo acousto-optic two-photon imaging of the retina in the human eye, Optics Express 23(9), 23436–23449 (2015 )
Patents
Fülep, Csilla ; Erdei, Gábor
MEASURING VISUAL ACUITY OF A CLIENT
WO/2018/020281 , Year of filing (patent): 2016 , Application number: PCT/HU2016/000050
Rózsa, Balázs ; Maák, Pál ; Soldier, Gergely
OPTICAL MICROSCOPE SYSTEM FOR SIMULTANEOUS OBSERVATION OF SPATIALLY DISTINCT REGIONS OF INTEREST
WO/2015/079268 , Year of filing (patent): 2013 , Application number: PCT/HU2013/000114
Katona, Gergely ; Maák, Pál ; Rozsa, Balázs
Method for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope and such measuring device
EP2798443 , Year of filing (patent): 2012 , Application number: PCT/HU2012/000002
Balázs, Rózsa ; Katona, Gergely ; Veress, Máté ; Maák, Pál ; Szalay, Gergely
Method for scanning along a continuous scanning trajectory with a scanner system
US20150085346 , Year of filing (patent): 2012 , Application number: PCT/HU2012/000001
Awards
Gábor Erdei, Innovation Award of Pro Progressio Foundation, 2018
Pál Maák, Ágoston Budó Prize of the Eötvös Lorán Physical Society, 2017
Journals
Biomedical Optics Express,
Signal-Image,
Optical Engineering,
Optics Express,
Scientific Report
Infrastructure
Femtosecond laser system (55 fs, 1.3 W),
BME AFT Quantum Optical Laboratory, single photon source and entangled photon pair source
HunQuTech: Production, sharing and development of quantum information networks
2017-1.2.1-NKP-2017-00001 (NKFIA, 2017-2021)
National Bionics Programme, NBP 24 (NKFIA, 2018-2020)
Developments in medical research for effective cataract treatment VKSZ-12-1-2013 (NKFIA, 2013-2017)
Fluorescent dyes and development of high-resolution, high-angle 3D two-photon microscopy for scanning human brain diagnostics for the treatment of epilepsy NVKP_16-1-16-0043 (NKFIH, 2017-2019)
Industry relations
Femtonics Ltd.
Medicontur Ltd.
Brain Vision Center, Hungary
Friedrich Miescher Institute, Switzerland
Conferences
Holló, Tamás Csaba ; Sarkadi, Tamás ; Erdei, Gábor
Increasing the correlation level of polarization entangled photon pairs generated by type-II SPDC in BBO
Frontiers in Optics / Laser Science, Washington, USA, (2020) Leading author
Nagy, D.; Szalay, G. ; Marosi, M. ; Plauška, A. ; Pinke, D.; Csupernyák, Cs. ; Heizer, B.; Bojdán, A. ; Horváth, G. ; Tompa, T. ; Maák P. et al.
Longterm Calcium Imaging With 3D-Acousto-Optic Microscopy at more than 1 mm Cortical Depth During Learning
16th Annual Conference of the Hungarian Neuroscience Society, Hungarian Academy of Sciences, Debrecen
(2019) co-author
Ócsai, K. ; Plauška, A. ; Szalay, G. ; Marosi, M. ; Tompa, T. ; Judák, L. ; Pinke, D.; Nagy, D.; Csupernyák, Cs. ; Heizer, B.; Maák P. et al.
Signal shape based functional neuron clusters from two photon imaging of learning mice
16th Annual Conference of the Hungarian Neuroscience Society, Hungarian Academy of Sciences, Debrecen
(2019) co-author
Szalay, G. ; Szadai, Z. ; Judák, L. ; Maák, P. ; Ócsai, K. ; Veress, M. ; Tompa, T. ; Chiovini, B. ; Katona, G. ; Rózsa, B.
Fast 3D imaging and photostimulation by 3D acousto-optical microscopy revealed spatiotemporally orchestrated clusters in the visual cortex
Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)
Washington DC, USA (2019) co-author
Timár-Fülep, C. ; Erdei, G.
Investigation of the effect of pupil diameter on visual acuity using a neuro-physiological model of the human eye
Society for Imaging Science and Technology Burlingame CA, USA (2019) leading author
A., Plauska ; G., Szalay ; M., Marosi ; T., Tompa ; D., Pinke ; G., Horváth ; D., Nagy ; C., Csupernyák ; B., Heizler ; L., Judák; P. Maák et al.
Multi-day, stable, functional neuronal network measurement in three dimensions from a depth exceeding 1mm
In: SFN 2018 - the annual meeting of the SOCIETY OF NEUROSCIENCE, San Diego CA (2018) co-author
